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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2AK4
All Species:
9.7
Human Site:
T690
Identified Species:
21.33
UniProt:
Q9P2K8
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9P2K8
NP_001013725.2
1649
186838
T690
R
G
Q
P
A
S
D
T
D
G
L
D
S
V
E
Chimpanzee
Pan troglodytes
XP_001140245
1649
186793
T690
R
G
Q
P
A
S
D
T
D
G
L
D
S
V
E
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_535431
1633
184740
S693
Q
P
S
P
G
N
D
S
P
D
G
D
G
A
G
Cat
Felis silvestris
Mouse
Mus musculus
Q9QZ05
1648
186468
D688
T
C
G
K
T
S
G
D
T
E
E
L
G
S
V
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518247
1608
180821
P649
H
L
D
G
M
G
L
P
A
G
D
V
E
T
S
Chicken
Gallus gallus
XP_421203
1656
188583
I696
T
P
T
K
A
G
L
I
L
T
A
E
E
T
N
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002667149
1483
168725
Y587
H
E
N
I
V
R
Y
Y
N
A
W
I
E
R
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001120977
1130
130476
M234
L
M
Q
N
L
L
R
M
D
S
S
D
S
I
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_785160
1605
181469
T703
E
E
P
P
T
T
D
T
D
E
S
R
T
T
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LX30
1241
140303
T345
H
L
L
R
V
A
C
T
S
R
G
P
L
A
D
Baker's Yeast
Sacchar. cerevisiae
P15442
1659
190175
M668
A
W
L
E
E
D
S
M
D
E
N
V
F
E
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
N.A.
89.7
N.A.
90.5
N.A.
N.A.
74.7
72.3
N.A.
52.6
N.A.
N.A.
27.9
N.A.
40.4
Protein Similarity:
100
99.9
N.A.
94.3
N.A.
94.9
N.A.
N.A.
84.4
84.5
N.A.
67.4
N.A.
N.A.
44
N.A.
59.4
P-Site Identity:
100
100
N.A.
20
N.A.
6.6
N.A.
N.A.
6.6
6.6
N.A.
0
N.A.
N.A.
33.3
N.A.
26.6
P-Site Similarity:
100
100
N.A.
40
N.A.
6.6
N.A.
N.A.
6.6
13.3
N.A.
13.3
N.A.
N.A.
40
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.5
26.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.7
46.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
0
28
10
0
0
10
10
10
0
0
19
0
% A
% Cys:
0
10
0
0
0
0
10
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
10
0
0
10
37
10
46
10
10
37
0
0
10
% D
% Glu:
10
19
0
10
10
0
0
0
0
28
10
10
28
10
28
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% F
% Gly:
0
19
10
10
10
19
10
0
0
28
19
0
19
0
19
% G
% His:
28
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
10
0
0
0
10
0
0
0
10
0
10
0
% I
% Lys:
0
0
0
19
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
10
19
19
0
10
10
19
0
10
0
19
10
10
0
0
% L
% Met:
0
10
0
0
10
0
0
19
0
0
0
0
0
0
0
% M
% Asn:
0
0
10
10
0
10
0
0
10
0
10
0
0
0
10
% N
% Pro:
0
19
10
37
0
0
0
10
10
0
0
10
0
0
0
% P
% Gln:
10
0
28
0
0
0
0
0
0
0
0
0
0
0
10
% Q
% Arg:
19
0
0
10
0
10
10
0
0
10
0
10
0
10
0
% R
% Ser:
0
0
10
0
0
28
10
10
10
10
19
0
28
10
19
% S
% Thr:
19
0
10
0
19
10
0
37
10
10
0
0
10
28
0
% T
% Val:
0
0
0
0
19
0
0
0
0
0
0
19
0
19
10
% V
% Trp:
0
10
0
0
0
0
0
0
0
0
10
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
10
10
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _